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Table I.

Characteristics of HIES patients

	HIES 1	HIES 2	HIES 3	HIES 4	HIES 5
Age	18	18	15	7	42
Sex	M	M	M	F	F
Infection
Candidiasis	Yes	No	Yes	Yes	Yes
S. aureus pneumonia	Yes	Yes	No	No	Yes
S. aureus abscesses	Yes	Yes	Yes	Yes	Yes
Other serious infection	No	No	No	No	No
Parenchymal lung damage	Yes	Yes	No	No	Yes
Characteristic face	Yes	Yes	Yes	Yes	Yes
Retained primary teeth	Yes	Yes	Yes	—	Yes
Fractures	Yes	Yes	Yes	No	No
Phenotype score (21)	71	50	54	26	63
IgE (kIU/L)	18,314	37,620	2,545	8,075	7,491
Genotype	V432M	R382Q	R382Q	H437P	Q644P
Affected STAT3 domain	DNABD	DNABD	DNABD	DNABD	SH2

	HIES 1	HIES 2	HIES 3	HIES 4	HIES 5
Age	18	18	15	7	42
Sex	M	M	M	F	F
Infection
Candidiasis	Yes	No	Yes	Yes	Yes
S. aureus pneumonia	Yes	Yes	No	No	Yes
S. aureus abscesses	Yes	Yes	Yes	Yes	Yes
Other serious infection	No	No	No	No	No
Parenchymal lung damage	Yes	Yes	No	No	Yes
Characteristic face	Yes	Yes	Yes	Yes	Yes
Retained primary teeth	Yes	Yes	Yes	—	Yes
Fractures	Yes	Yes	Yes	No	No
Phenotype score (21)	71	50	54	26	63
IgE (kIU/L)	18,314	37,620	2,545	8,075	7,491
Genotype	V432M	R382Q	R382Q	H437P	Q644P
Affected STAT3 domain	DNABD	DNABD	DNABD	DNABD	SH2

DNABD, DNA binding domain; SH2, src homology 2 domain.