Functional analysis of WT mice treated with AdR5 or AdSPARC virus
| Sham | MI, 14 d | |||
| AdR5, n = 4 | AdSPARC, n = 4 | AdR5, n = 9 | AdSPARC, n = 9 | |
| FS (%) | 22 ± 2.5 | 30 ± 2.0a | 10 ± 1.7a | 24 ± 3.4b |
| LVIDd (mm) | 3.9 ± 0.1 | 4.1 ± 0.1 | 5.8 ± 0.2a | 5.0 ± 0.2ab |
| LVIDs (mm) | 3.0 ± 0.1 | 2.9 ± 0.1 | 5.2 ± 0.2a | 3.8 ± 0.3ab |
| PWd (mm) | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1a |
| IVSd (mm) | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1b |
| HW/BW | 3.9 ± 0.1 | 4.3 ± 0.2 | 5.1 ± 0.2a | 4.8 ± 0.1a |
| LW/BW | 5.7 ± 0.1 | 5.5 ± 0.1 | 7.0 ± 0.5a | 5.3 ± 0.1b |
| Sham | MI, 14 d | |||
| AdR5, n = 4 | AdSPARC, n = 4 | AdR5, n = 9 | AdSPARC, n = 9 | |
| FS (%) | 22 ± 2.5 | 30 ± 2.0a | 10 ± 1.7a | 24 ± 3.4b |
| LVIDd (mm) | 3.9 ± 0.1 | 4.1 ± 0.1 | 5.8 ± 0.2a | 5.0 ± 0.2ab |
| LVIDs (mm) | 3.0 ± 0.1 | 2.9 ± 0.1 | 5.2 ± 0.2a | 3.8 ± 0.3ab |
| PWd (mm) | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1a |
| IVSd (mm) | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1b |
| HW/BW | 3.9 ± 0.1 | 4.3 ± 0.2 | 5.1 ± 0.2a | 4.8 ± 0.1a |
| LW/BW | 5.7 ± 0.1 | 5.5 ± 0.1 | 7.0 ± 0.5a | 5.3 ± 0.1b |
FS, fractional shortening; LVIDd, left ventricular internal diameter diastole; LVIDs, left ventricular internal diameter systole; PWd, posterior wall diastole IVSd, intraventricular septum diastole; HW, heart weight; BW, body weight; and LW, lung weight.
P < 0.05 in infarcted (MI) versus sham-operated mice or AdR5 versus AdSPARC sham-operated mice.
P < 0.05 in AdvSPARC infarcts versus AdR5 infarcts.