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Table I.

Arthritis development following TnfΔARE BM reconstitution of lethally irradiated recipients

Donor genotype
Recipient genotype
Arthritis development
WT WT 0/20 
TnfΔARE/+ WT 19/21 
TnfΔARE/ΔARE TnfRI−/− WT 25/25 
TnfΔARE/+ TnfRI−/− 0/8 
Donor genotype
Recipient genotype
Arthritis development
WT WT 0/20 
TnfΔARE/+ WT 19/21 
TnfΔARE/ΔARE TnfRI−/− WT 25/25 
TnfΔARE/+ TnfRI−/− 0/8 

BM isolated from 2-mo-old female B6,129 mice (donor genotype) was engrafted into 6–8-wk-old syngeneic, lethally irradiated, female mice (recipient genotype). Assessment of arthritis development was based on histopathological evaluation of joint samples at 12 wk after transfer.

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