Table II
Structural Requirements for Use-dependent Block
| Position | Substituent | Side chain | I12/I1 | n | ||||
|---|---|---|---|---|---|---|---|---|
    | 100 mV | |||||||
| I | Isoleucine | 0.34 ± 0.03 | 3 | |||||
| Alanine | 0.87 ± 0.04 | 4 | ||||||
| F | ||||||||
| Phenylglycine | 0.64 ± 0.03 | 6 | ||||||
| Phenylalanine | 0.34 ± 0.03 | 3 | ||||||
| (4-NH2)-Phenylalanine | 0.95 ± 0.06 | 3 | ||||||
| Diphenylalanine | 0.62 ± 0.04 | 3 | ||||||
| Tryptophan | 0.40 ± 0.08 | 3 | ||||||
| L-Tetrahydroisoquiniline* | 0.79 ± 0.04 | 4 | ||||||
| M | ||||||||
| Methionine | 0.34 ± 0.03 | 3 | ||||||
| (S-oxo)-Methionine | 0.94 ± 0.05 | 4 | ||||||
| Ornithine | 0.68 ± 0.06 | 3 | ||||||
| Norleucine | 0.36 ± 0.04 | 3 | ||||||
| Alanine | 0.78 ± 0.07 | 3 |
| Position | Substituent | Side chain | I12/I1 | n | ||||
|---|---|---|---|---|---|---|---|---|
| | 100 mV | |||||||
| I | Isoleucine | 0.34 ± 0.03 | 3 | |||||
| Alanine | 0.87 ± 0.04 | 4 | ||||||
| F | ||||||||
| Phenylglycine | 0.64 ± 0.03 | 6 | ||||||
| Phenylalanine | 0.34 ± 0.03 | 3 | ||||||
| (4-NH2)-Phenylalanine | 0.95 ± 0.06 | 3 | ||||||
| Diphenylalanine | 0.62 ± 0.04 | 3 | ||||||
| Tryptophan | 0.40 ± 0.08 | 3 | ||||||
| L-Tetrahydroisoquiniline* | 0.79 ± 0.04 | 4 | ||||||
| M | ||||||||
| Methionine | 0.34 ± 0.03 | 3 | ||||||
| (S-oxo)-Methionine | 0.94 ± 0.05 | 4 | ||||||
| Ornithine | 0.68 ± 0.06 | 3 | ||||||
| Norleucine | 0.36 ± 0.04 | 3 | ||||||
| Alanine | 0.78 ± 0.07 | 3 |
*
Structure represents the entire amino acid residue rather than just the side chain.