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Table III

Parameter Estimates for Scheme 3+2′

Partial chargeWT's rate at 0 mVV2's rate at 0 mV
e0  s−1  s−1 
For S0↔ S1, S1↔ S2, and S2↔ S3     
qa1 = 0.47  a1(0) = 1650 (c = 1.3)  a1(0) = 1450 (c
qb1 = −0.52  b1(0) = 450 (1/c b1(0) = 450 (1/c
qa2 = 0.08  a2(0) = 4900  a2(0) = 4270 
qb2 = −0.52  b2(0) = 960  b2(0) = 960 
qa3 = 0.08  a3(0) = 7920  a3(0) = 6980 
qb3 = −0.52  b3(0) = 1560  b3(0) = 1560 
For the transitions near the open state     
q αN-1 = 0.75   αN-1(0) = 7000       αN-1(0) = 3800 
q βN-1 = −0.30   βN-1(0) = 340       βN-1(0) = 19000 
q αN = 0.18    αN(0) = 7000  αN(0) = 3800 
q βN = −0.52    βN(0) = 240  βN(0) = 650 
qc = 0.2  c(0) = 7  c(0) = 17 
qd = 0.0  d(0) = 600  d(0) = 600 
qe1 = 0.0    e1(0) = 230  e1(0) = 400 
qf1 = 0.20    f1(0) = 3500  f1(0) = 3500 
qe2 = 0.0    e2(0) = 600  e2(0) = 600 
qf2 = 0.0    f2(0) = 7000  f2(0) = 7000 
Partial chargeWT's rate at 0 mVV2's rate at 0 mV
e0  s−1  s−1 
For S0↔ S1, S1↔ S2, and S2↔ S3     
qa1 = 0.47  a1(0) = 1650 (c = 1.3)  a1(0) = 1450 (c
qb1 = −0.52  b1(0) = 450 (1/c b1(0) = 450 (1/c
qa2 = 0.08  a2(0) = 4900  a2(0) = 4270 
qb2 = −0.52  b2(0) = 960  b2(0) = 960 
qa3 = 0.08  a3(0) = 7920  a3(0) = 6980 
qb3 = −0.52  b3(0) = 1560  b3(0) = 1560 
For the transitions near the open state     
q αN-1 = 0.75   αN-1(0) = 7000       αN-1(0) = 3800 
q βN-1 = −0.30   βN-1(0) = 340       βN-1(0) = 19000 
q αN = 0.18    αN(0) = 7000  αN(0) = 3800 
q βN = −0.52    βN(0) = 240  βN(0) = 650 
qc = 0.2  c(0) = 7  c(0) = 17 
qd = 0.0  d(0) = 600  d(0) = 600 
qe1 = 0.0    e1(0) = 230  e1(0) = 400 
qf1 = 0.20    f1(0) = 3500  f1(0) = 3500 
qe2 = 0.0    e2(0) = 600  e2(0) = 600 
qf2 = 0.0    f2(0) = 7000  f2(0) = 7000 

The parameter c reflects a small amount of cooperative interaction, which has been introduced into S0↔ S1, as shown in Scheme I. 

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