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Table III.

Exemplar parameters that provide good fits to the six target measures

Molecule Model name Concentrations 
Fixed Concentrations 
Nascent nAChRs C1 unfolded 10−5
Endogenous ERES ERES0 8 × 10−4
Export Machinery ExMach00 9.0 × 10−3
“Endogenous” nicotine Nicotine0 3.3 nM 
Optical parameter 
Fraction of ER fluorescence detected by TIRF ER_fractional_signal 0.14 
Molecule Model name Concentrations 
Fixed Concentrations 
Nascent nAChRs C1 unfolded 10−5
Endogenous ERES ERES0 8 × 10−4
Export Machinery ExMach00 9.0 × 10−3
“Endogenous” nicotine Nicotine0 3.3 nM 
Optical parameter 
Fraction of ER fluorescence detected by TIRF ER_fractional_signal 0.14 

See model Fig. 7 A.

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