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Table II.

dSlo mediates the difference in synaptic transmission between mutIP1 and WTP41 flies

Fly genotype/treatment EJC amplitude mEJC frequency mEJC amplitude 
 nA Hz nA 
WTP41 11.17 ± 0.73 (37) 0.94 ± 0.09 (48) 0.26 ± 0.02 (34) 
mutIP1 14.69 ± 0.62 (45)** 1.59 ± 0.17 (33)** 0.35 ± 0.02 (40)* 
WTP41;Slo4 11.59 ± 0.94 (10) 1.45 ± 0.22 (13) 0.28 ± 0.02 (13) 
mutIP1;Slo4 13.29 ± 1.11 (15) 1.68 ± 0.29 (10) 0.34 ± 0.02 (10) 
WTP41+TEA 10.39 ± 0.84 (14) 1.17 ± 0.19 (14) 0.24 ± 0.02 (10) 
mutIP1+TEA 11.72 ± 0.48 (38) 1.55 ± 0.17 (32) 0.28 ± 0.01 (34) 
Fly genotype/treatment EJC amplitude mEJC frequency mEJC amplitude 
 nA Hz nA 
WTP41 11.17 ± 0.73 (37) 0.94 ± 0.09 (48) 0.26 ± 0.02 (34) 
mutIP1 14.69 ± 0.62 (45)** 1.59 ± 0.17 (33)** 0.35 ± 0.02 (40)* 
WTP41;Slo4 11.59 ± 0.94 (10) 1.45 ± 0.22 (13) 0.28 ± 0.02 (13) 
mutIP1;Slo4 13.29 ± 1.11 (15) 1.68 ± 0.29 (10) 0.34 ± 0.02 (10) 
WTP41+TEA 10.39 ± 0.84 (14) 1.17 ± 0.19 (14) 0.24 ± 0.02 (10) 
mutIP1+TEA 11.72 ± 0.48 (38) 1.55 ± 0.17 (32) 0.28 ± 0.01 (34) 

Slo4 genetic background, or TEA application, abolish the effects of Slob on EJC amplitude and on the frequency and amplitude of the mEJC. As indicated by the asterisks, the mutIP1 group is significantly different from the WTP41 group, with respect to all parameters measured. The inhibition of dSlo either genetically (Slo4 flies) or pharmacologically (1 mM TEA) eliminates the differences and makes Slob knockout and WT flies statistically indistinguishable. Mean ± SEM is shown for each group. Cell numbers are in parentheses. For averaged EJC traces and sample mEJC traces, see Fig. 8.

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