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Table I.

Effect of CO on MCT-induced changes in body weights, cardiac weights, and pulmonary hemodynamics in rats


No MCT
MCT



Air
CO
Air
CO
 (days 1–14)
CO
 (days 15–28)
CO
 (days 29–42)
Number (n
BW (g) 288 ± 31 291 ± 37 249 ± 52 303 ± 56 296 ± 53 301 ± 70 
mPAP (mmHg) 15.8 ± 0.75 16.1 ± 1.0 34.6 ± 2.8# 15 ± 2* 19.8 ± 2.7* 21.1 ± 4.0* 
RV mass (mg) 143 ± 21 137 ± 19 414 ± 27# 165 ± 21* 207 ± 51* 214 ± 59* 
LV + IVS (mg) 524 ± 29 530 ± 33 696 ± 15 617 ± 178 639 ± 196 690 ± 156 
RV/BW 0.49 ± 0.01 0.47 ± 0.04 1.66 ± 0.15# 0.54 ± 0.06* 0.69 ± 0.1* 0.71 ± 0.2* 
RV/LV + IVS 0.26 ± 0.01 0.26 ± 0.03 0.60 ± 0.05# 0.28 ± 0.05* 0.33 ± 0.06* 0.31 ± 0.07* 

No MCT
MCT



Air
CO
Air
CO
 (days 1–14)
CO
 (days 15–28)
CO
 (days 29–42)
Number (n
BW (g) 288 ± 31 291 ± 37 249 ± 52 303 ± 56 296 ± 53 301 ± 70 
mPAP (mmHg) 15.8 ± 0.75 16.1 ± 1.0 34.6 ± 2.8# 15 ± 2* 19.8 ± 2.7* 21.1 ± 4.0* 
RV mass (mg) 143 ± 21 137 ± 19 414 ± 27# 165 ± 21* 207 ± 51* 214 ± 59* 
LV + IVS (mg) 524 ± 29 530 ± 33 696 ± 15 617 ± 178 639 ± 196 690 ± 156 
RV/BW 0.49 ± 0.01 0.47 ± 0.04 1.66 ± 0.15# 0.54 ± 0.06* 0.69 ± 0.1* 0.71 ± 0.2* 
RV/LV + IVS 0.26 ± 0.01 0.26 ± 0.03 0.60 ± 0.05# 0.28 ± 0.05* 0.33 ± 0.06* 0.31 ± 0.07* 

PAH was assessed on day 43 following MCT treatment. MCT induced significant PAH (air vs. no MCT) as assayed by mPAP, RV mass, and the ratios of RV/BW and RV/LV + IVS. CO treatment, when started on days 1–14, 15–28, or 29–42, prevented or reversed MCT-induced changes in the heart and lung parameters listed. n = number of animals/group. #, P < 0.01 versus no MCT; and *, P < 0.01 versus air + MCT. BW, body weight.

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