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Table IV.

OspA163–175 peptide binding of HLA-DRB1 genotypes in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis

DRB genotypesNumber of positive patients
OR (95% CI)P value

Antibiotic
 refractory
Antibiotic
 responsive


 % %   
Two known OspA-binding alleles versus two known nonbinding alleles n = 18 n = 13   
    (1) Both alleles bind 15 (83) 4 (31) 11.3 (2.14, 58.8) 0.008 
    (2) Neither allele binds 3 (17) 9 (69)   
One known OspA-binding allele versus one known nonbinding or
     unknown binding allele n= 53 n= 37   
    (3) One binding/one non- or unknown binding allelea 41 (77) 19 (51) 3.2 (1.3, 8.0) 0.013 
    (4) One nonbinding/one unknown binding allele 12 (23) 18 (49)   
All patients n = 71 n = 50   
1 and 3: one or two known binding alleles 56 (79) 23 (46) 4.4 (1.99, 9.66) <0.001 
2 and 4: no known binding alleles 15 (21) 27 (54)   
DRB genotypesNumber of positive patients
OR (95% CI)P value

Antibiotic
 refractory
Antibiotic
 responsive


 % %   
Two known OspA-binding alleles versus two known nonbinding alleles n = 18 n = 13   
    (1) Both alleles bind 15 (83) 4 (31) 11.3 (2.14, 58.8) 0.008 
    (2) Neither allele binds 3 (17) 9 (69)   
One known OspA-binding allele versus one known nonbinding or
     unknown binding allele n= 53 n= 37   
    (3) One binding/one non- or unknown binding allelea 41 (77) 19 (51) 3.2 (1.3, 8.0) 0.013 
    (4) One nonbinding/one unknown binding allele 12 (23) 18 (49)   
All patients n = 71 n = 50   
1 and 3: one or two known binding alleles 56 (79) 23 (46) 4.4 (1.99, 9.66) <0.001 
2 and 4: no known binding alleles 15 (21) 27 (54)   
a

Among the antibiotic-refractory patients, 22 had one known OspA-binding allele and one known non-OspA–binding allele, and 19 had one known OspA-binding allele and one allele that was not yet possible to test for binding. Among the antibiotic-responsive patients, 16 had a known OspA-binding allele and one known nonbinding allele, and three had one known OspA-binding allele and one allele that was not possible to test for binding.

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