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Table III.

Comparison of HLA-DR specificities and alleles according to disease course in past and current patients with Lyme arthritisa

HLA-DR
 specificity
Past patients with
 Lyme arthritis
OR (95% CI)HLA-DRB1 allelesCurrent patients with
 Lyme arthritis
OR (95% CI)

Moderate or
 prolongedb
Briefc


Antibiotic
 refractoryd
Antibiotic
 responsivee

 % %   % %  
DR1 21 18 1.17 (0.35, 3.89) 0101, 0102, 0103 28 18 1.79 (0.75, 4.27) 
DR2 41 18 3.18 (0.99, 10.04) 1501, 1502, 1601 32 20 1.92 (0.83, 4.43) 
DR3 21 23 0.89 (0.28, 2.77) 0301 20 32 0.51 (0.23, 1.19) 
DR4 40 6.75 (1.54, ND)f 401/02/03/04/05/06/07/08/
     09/16 46 26 2.47 (1.13, 5.37) 
DR5 17 32 0.45 (0.15, 1.34) 1101/02/03/04, 1201 17 36 0.36 (0.16, 0.84) 
DR7 14 18 0.72 (0.20, 2.52) 0701 23 18 1.33 (0.54, 3.24) 
HLA-DR
 specificity
Past patients with
 Lyme arthritis
OR (95% CI)HLA-DRB1 allelesCurrent patients with
 Lyme arthritis
OR (95% CI)

Moderate or
 prolongedb
Briefc


Antibiotic
 refractoryd
Antibiotic
 responsivee

 % %   % %  
DR1 21 18 1.17 (0.35, 3.89) 0101, 0102, 0103 28 18 1.79 (0.75, 4.27) 
DR2 41 18 3.18 (0.99, 10.04) 1501, 1502, 1601 32 20 1.92 (0.83, 4.43) 
DR3 21 23 0.89 (0.28, 2.77) 0301 20 32 0.51 (0.23, 1.19) 
DR4 40 6.75 (1.54, ND)f 401/02/03/04/05/06/07/08/
     09/16 46 26 2.47 (1.13, 5.37) 
DR5 17 32 0.45 (0.15, 1.34) 1101/02/03/04, 1201 17 36 0.36 (0.16, 0.84) 
DR7 14 18 0.72 (0.20, 2.52) 0701 23 18 1.33 (0.54, 3.24) 
a

The results in past patients were published previously (7). The 80 patients were stratified according to the longest single attack of arthritis. Analogous to the current definition of antibiotic-responsive arthritis, arthritis of ≤3-mo duration in past patients was defined as arthritis of brief duration, and analogous to the current definition of antibiotic-refractory arthritis, arthritis lasting 4 mo to 4 yr in past patients was defined as arthritis of moderate or prolonged duration.

b

n = 58.

c

n = 22.

d

n = 71.

e

n = 50.

f

The number of patients with the DR4 specificity in the brief group was too small to calculate a reliable upper CI.

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