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Table II.

DRB1 allele frequencies in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis

DRB1aAllele frequencies
G value
Lyme arthritis patients

Antibiotic
 refractoryb
Antibiotic
 responsivec

 % %  
0101 11.3 4.1 
0102 1.4 2.0  
0103 0.7 3.1 
0301 10.6 14 0.6 
0401 12.7 2.8 
0402 2.8 0  
0403 0.7 0  
0404 6.3 0.0 
0405 1.4 0  
0407 2.1 0  
0408 0 1  
0409 0.7 0  
0416 0 1  
0701 12.0 0.5 
0801 0.7 5.9 
0901  
1101 2.8 4.1 
1102 0.7 0  
1103 0.7 0  
1104 1.4 5.0 
1201 2.8 0.2 
1301 4.2 0.0 
1302 2.1 3.4 
1303 2.1 0.2 
1401 1.4 0.7 
1501 14.1 1.3 
1502 1.4 0  
1601 2.1 0.0 
Combined 7.4 5  
Total 100.0 100.0 31.9 
P value   0.006a 
Degree of freedom   15 
Wn effect size
     statistic   0.38 
DRB1aAllele frequencies
G value
Lyme arthritis patients

Antibiotic
 refractoryb
Antibiotic
 responsivec

 % %  
0101 11.3 4.1 
0102 1.4 2.0  
0103 0.7 3.1 
0301 10.6 14 0.6 
0401 12.7 2.8 
0402 2.8 0  
0403 0.7 0  
0404 6.3 0.0 
0405 1.4 0  
0407 2.1 0  
0408 0 1  
0409 0.7 0  
0416 0 1  
0701 12.0 0.5 
0801 0.7 5.9 
0901  
1101 2.8 4.1 
1102 0.7 0  
1103 0.7 0  
1104 1.4 5.0 
1201 2.8 0.2 
1301 4.2 0.0 
1302 2.1 3.4 
1303 2.1 0.2 
1401 1.4 0.7 
1501 14.1 1.3 
1502 1.4 0  
1601 2.1 0.0 
Combined 7.4 5  
Total 100.0 100.0 31.9 
P value   0.006a 
Degree of freedom   15 
Wn effect size
     statistic   0.38 

When less than or equal to five individuals with Lyme arthritis had a given haplotype, the values were excluded from analysis (empty cells). These rare alleles, which consisted of 7.4% of the total alleles in the refractory group and 5.0% of those in the responsive group, were excluded from the statistical analysis. Rare DRB1 alleles and their combined sum are listed in italics.

a

For G statistic verification, the 2 × 15 table was also calculated by an exact test; P = 0.008.

b

n = 142.

c

n = 100.

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