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Table III.

mAb subclasses generated by the immunization with irradiated sporozoites or with αDEC-CS plus maturation stimulus


Immunization methoda

Positive clones against the major repeat (%)b

Positive clones against the minor repeat (%)b
 IgG1 IgG2a IgG2b IgG3 IgG1 IgG2a IgG2b IgG3 
Irradiated sporozoites 70 10 20 
αDEC-CS+anti-CD40+poly I:C
 
56.7
 
9
 
7.5
 
26.9
 
25.9
 
25.9
 
40.7
 
7.4
 

Immunization methoda

Positive clones against the major repeat (%)b

Positive clones against the minor repeat (%)b
 IgG1 IgG2a IgG2b IgG3 IgG1 IgG2a IgG2b IgG3 
Irradiated sporozoites 70 10 20 
αDEC-CS+anti-CD40+poly I:C
 
56.7
 
9
 
7.5
 
26.9
 
25.9
 
25.9
 
40.7
 
7.4
 
a

Mice were immunized as described in Table II.

b

All positive clones were rescreened against the major and minor repeats of CSP using anti–mouse subclass-specific secondary antibodies.

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