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Table IV.

Distribution of CCR5Δ32 allele as a function of clinical outcome in WNV-seropositive patients



Genotype, n (%)
All racial groups
Self-reporting Caucasians
Clinical outcome
+/+
+/Δ32
Δ32/Δ32
+/+
+/Δ32
Δ32/Δ32
Fevera 85 (83.3) 12 (11.8) 5 (4.9) 52 (80.0) 9 (13.8) 4 (6.2) 
Meningitisa 100 (81.3) 19 (15.4) 4 (3.3) 59 (78.7) 13 (17.3) 3 (4.0) 
Encephalitisa 82 (71.9) 27 (23.7) 5 (4.4) 48 (68.6) 17 (24.3) 5 (7.1) 
Not Specifieda 49 (87.5) 4 (7.1) 3 (5.4) 5 (100.0) 0 (0) 0 (0) 
Death 13 (68.4) 4 (21.1) 2 (10.5) 6 (75.0) 0 (0) 2 (25.0) 
Total
 
316 (80.0)
 
62 (15.7)
 
17 (4.3)
 
164 (76.3)
 
39 (18.1)
 
12 (5.6)
 


Genotype, n (%)
All racial groups
Self-reporting Caucasians
Clinical outcome
+/+
+/Δ32
Δ32/Δ32
+/+
+/Δ32
Δ32/Δ32
Fevera 85 (83.3) 12 (11.8) 5 (4.9) 52 (80.0) 9 (13.8) 4 (6.2) 
Meningitisa 100 (81.3) 19 (15.4) 4 (3.3) 59 (78.7) 13 (17.3) 3 (4.0) 
Encephalitisa 82 (71.9) 27 (23.7) 5 (4.4) 48 (68.6) 17 (24.3) 5 (7.1) 
Not Specifieda 49 (87.5) 4 (7.1) 3 (5.4) 5 (100.0) 0 (0) 0 (0) 
Death 13 (68.4) 4 (21.1) 2 (10.5) 6 (75.0) 0 (0) 2 (25.0) 
Total
 
316 (80.0)
 
62 (15.7)
 
17 (4.3)
 
164 (76.3)
 
39 (18.1)
 
12 (5.6)
 

Data were pooled from the Arizona and Colorado cohorts.

a

Patients were classified into one of the four indicated disease categories by interview with the referring physician. +, wild-type CCR5 allele; Δ32, CCR5Δ32 allele.

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