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Table I.

Average absolute number of CD4+, CD4+CD25+, CD25+CD62Lhi, and CD25+CD62Llo per 10,000 lymphocytes within the PLNs of NOD female and NOD male mice



Average absolute number
4 wk8 wk16 wkDiabetic

 
(%)
 
(%)
 
(%)
 
(%)
 
 NOD female PLN    
CD4+ 1,959 ± 118 2,895 ± 117 4,945 ± 425 7,070 ± 448 
CD25+ 156 ± 20 291 ± 57 495 ± 71 654 ± 42 
CD25+CD62Lhi 54 ± 5 (34.6)a 101 ± 8 (34.7) 147 ± 10 (30.0) 140 ± 10 (21.4) 
FoxP3+CD25+CD62Lhi 37b 50 43 35 
CD25+CD62Llo 107 ± 8 (68.6)a 192 ± 11(66.0) 340 ± 13 (68.7) 510 ± 20 (78.0) 
FoxP3+CD25+CD62Llo 37b 44 61 63 
 NOD male PLN    
CD4+ 2,789 ± 109 ND 5,432 ± 306 ND 
CD25+ 251 ± 23 ND 456 ± 37 ND 
CD25+CD62Lhi 79 ± 7 (31.5)a ND 150 ± 13 (32.9) ND 
FoxP3+CD25+CD62Lhi 35b ND 53 ND 
CD25+CD62Llo 175 ± 10 (69.7)a ND 308 ± 27 (67.5) ND 
FoxP3+CD25+CD62Llo
 
37b
 
ND
 
49
 
ND
 


Average absolute number
4 wk8 wk16 wkDiabetic

 
(%)
 
(%)
 
(%)
 
(%)
 
 NOD female PLN    
CD4+ 1,959 ± 118 2,895 ± 117 4,945 ± 425 7,070 ± 448 
CD25+ 156 ± 20 291 ± 57 495 ± 71 654 ± 42 
CD25+CD62Lhi 54 ± 5 (34.6)a 101 ± 8 (34.7) 147 ± 10 (30.0) 140 ± 10 (21.4) 
FoxP3+CD25+CD62Lhi 37b 50 43 35 
CD25+CD62Llo 107 ± 8 (68.6)a 192 ± 11(66.0) 340 ± 13 (68.7) 510 ± 20 (78.0) 
FoxP3+CD25+CD62Llo 37b 44 61 63 
 NOD male PLN    
CD4+ 2,789 ± 109 ND 5,432 ± 306 ND 
CD25+ 251 ± 23 ND 456 ± 37 ND 
CD25+CD62Lhi 79 ± 7 (31.5)a ND 150 ± 13 (32.9) ND 
FoxP3+CD25+CD62Lhi 35b ND 53 ND 
CD25+CD62Llo 175 ± 10 (69.7)a ND 308 ± 27 (67.5) ND 
FoxP3+CD25+CD62Llo
 
37b
 
ND
 
49
 
ND
 
a

Percentage of CD4+CD25+ T cells. Data are an average of five experiments (female) or two experiments (male).

b

Estimated number based on average absolute number and average percent of FoxP3+.

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