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Table I.

Neutralization of IFN-γ dramatically reduced regulation by CD25+CD4+ T cells in vivo


Adoptive transfer





CD45RBhighCD25+Anti–IFN-γ mAbIsotypeEvidence of necrosis
 between days 7 and 11
 (>50% of graft)Graft survival timeGraft survival at 100 d

 

 

 

 

 
d
 

 
− − 8/8 9, 10, 11, 13, 4 × 17 0/8 
− − 4/4 4 × 9 0/4 
− 0/6 6× >100 6/6 
+
 
+
 
+
 

 
7/7
 
10, 2 × 11, 30, 3× >100
 
3/7a
 

Adoptive transfer





CD45RBhighCD25+Anti–IFN-γ mAbIsotypeEvidence of necrosis
 between days 7 and 11
 (>50% of graft)Graft survival timeGraft survival at 100 d

 

 

 

 

 
d
 

 
− − 8/8 9, 10, 11, 13, 4 × 17 0/8 
− − 4/4 4 × 9 0/4 
− 0/6 6× >100 6/6 
+
 
+
 
+
 

 
7/7
 
10, 2 × 11, 30, 3× >100
 
3/7a
 
a

P < 0.01.

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