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Table II.

Conservation of immunogenic proteins and determinants across poxvirus species and strains


VACV-WR

VACV-MVAa

CPXV-BR

ECTV-Mos

VARV-Bshb
Gene
Determinant
Genec
Determinantd
Gene
Determinant
Gene
Determinant
Gene
Determinant
B8R TSYKFESV NA/176  202  158 B8R 
A19L VSLDYINTM  130  152  122 A20L 
A47L AAFEFINSL  160  185  146 Ae J1L 
A42R YAPVSPIVI  154R  179  141 A45R 
K3L
 
YSLPNAGDVI
 
 024
 
Y
 
 043
 
Y
 
 NA
 
Y
 
C3L
 
Af
 

VACV-WR

VACV-MVAa

CPXV-BR

ECTV-Mos

VARV-Bshb
Gene
Determinant
Genec
Determinantd
Gene
Determinant
Gene
Determinant
Gene
Determinant
B8R TSYKFESV NA/176  202  158 B8R 
A19L VSLDYINTM  130  152  122 A20L 
A47L AAFEFINSL  160  185  146 Ae J1L 
A42R YAPVSPIVI  154R  179  141 A45R 
K3L
 
YSLPNAGDVI
 
 024
 
Y
 
 043
 
Y
 
 NA
 
Y
 
C3L
 
Af
 
a

VACV-MVA: two available sequences (U94848 and AY603355) agree except for B8R. CPX-BR: CPXV-Brighton red, ECTV-Mos: ECTV-Moscow, VARV-Bsh: VARV-Bangladesh.

b

VARV does not infect mice; determinant conservation is shown only for completeness.

c

Gene name given where annotated; NA: gene not included in annotation.

d

Y: Determinant conserved in genomic sequence; gene may or may not be intact or expressed.

e

A: Determinant is altered to ATFEFINSL.

f

A: Determinant is altered to YSLPNVGDVL.

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