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Table III.

Deletion of the Irak-M gene in mice leads to increased production of IL-1α and IL-1β by bone marrow macrophages that are stimulated with M-CSF




12 h

24 h


IRAK-M+/+
IRAK-M−/−
//+/+
IRAK-M+/+
IRAK-M−/−
//+/+
IL-1α M-CSF 1.09a 1.26a 1.15 0.53a 1.09a 2.06 
 M-CSF + RANKL 1.27a 1.26a 1.00 0.59a 1.06a 1.80 
IL-1β M-CSF 1.59a 2.08a 1.31 0.52a 0.91a 1.75 

 
M-CSF + RANKL
 
1.52a
 
1.90a
 
1.25
 
0.51a
 
1.02a
 
2.00
 



12 h

24 h


IRAK-M+/+
IRAK-M−/−
//+/+
IRAK-M+/+
IRAK-M−/−
//+/+
IL-1α M-CSF 1.09a 1.26a 1.15 0.53a 1.09a 2.06 
 M-CSF + RANKL 1.27a 1.26a 1.00 0.59a 1.06a 1.80 
IL-1β M-CSF 1.59a 2.08a 1.31 0.52a 0.91a 1.75 

 
M-CSF + RANKL
 
1.52a
 
1.90a
 
1.25
 
0.51a
 
1.02a
 
2.00
 
a

Values represent the ratios of 12-h or 24-h stimulation with M-CSF or M-CSF plus RANKL over controls (n = 2).

Each experiment was repeated three times with similar results.

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