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Table I.

Peripheral quantitative computed tomography analysis of femurs from 4-mo-old IRAK-M−/− and IRAK-M+/+ male and female mice




Femoral shaft

Distal femur
Cortical
 contentCortical
 densityCortical
 thicknessPeriosteal
 circumferenceEndosteal
 circumferenceTrabecular
 contentTrabecular
 density

 

 
mg/mm
 
mg/cm3
 
mm
 
mm
 
mm
 
mg/mm
 
mg/cm3
 
Male+/+ mean 1.985 1,235.6 0.375 5.462 3.107 0.72 291.65 
 SD 0.182 21.691 0.024 0.289 0.32 0.041 26.428 
Male−/− mean 1.325 1,173.375 0.337 4.409 2.292 0.295 141.925 
 SD 0.061 13.579 0.015 0.075 0.124 0.093 46.187 
//+/+  0.7 0.9 0.9 0.8 0.7 0.4 0.5 
p-value  <0.01 <0.01 <0.05   <0.01   <0.01  <0.001 <0.01 
Female+/+ mean 1.51 1,179.08 0.347 4.801 2.625 0.338 177.04 
 SD 0.067 30.548 0.021 0.318 0.42 0.025 19.802 
Female−/− mean 1.293 1,169.067 0.327 4.423 2.369 0.107 62.167 
 SD 0.035 18.003 0.01 0.077 0.135 0.078 47.218 
//+/+  0.9 0.9 0.9 0.9 0.3 0.4 
p-value
 

 
<0.01
 
NS
 
NS
 
  <0.05
 
NS
 
<0.01
 
<0.05
 



Femoral shaft

Distal femur
Cortical
 contentCortical
 densityCortical
 thicknessPeriosteal
 circumferenceEndosteal
 circumferenceTrabecular
 contentTrabecular
 density

 

 
mg/mm
 
mg/cm3
 
mm
 
mm
 
mm
 
mg/mm
 
mg/cm3
 
Male+/+ mean 1.985 1,235.6 0.375 5.462 3.107 0.72 291.65 
 SD 0.182 21.691 0.024 0.289 0.32 0.041 26.428 
Male−/− mean 1.325 1,173.375 0.337 4.409 2.292 0.295 141.925 
 SD 0.061 13.579 0.015 0.075 0.124 0.093 46.187 
//+/+  0.7 0.9 0.9 0.8 0.7 0.4 0.5 
p-value  <0.01 <0.01 <0.05   <0.01   <0.01  <0.001 <0.01 
Female+/+ mean 1.51 1,179.08 0.347 4.801 2.625 0.338 177.04 
 SD 0.067 30.548 0.021 0.318 0.42 0.025 19.802 
Female−/− mean 1.293 1,169.067 0.327 4.423 2.369 0.107 62.167 
 SD 0.035 18.003 0.01 0.077 0.135 0.078 47.218 
//+/+  0.9 0.9 0.9 0.9 0.3 0.4 
p-value
 

 
<0.01
 
NS
 
NS
 
  <0.05
 
NS
 
<0.01
 
<0.05
 
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