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Table I.

HCV-1 Epitopes and Disease Status of Study Animals


Animal

Patr allele

HCV region

Wild-type sequence/
 escape mutations

Month of detection

Status
CBO603 A*0901 NS41963–1972 QWISSECTTPC/
 ----------- (8/24)
 ------S---- (2/24)
 --L-----A—- (1/24)
 --L-------- (13/24) 63a chronic 
CH-503 A*0401 E2588–596 KHPDATYSR/
 -------T- (9/9) 21 chronic 
 B*1601 E1233–241 GNASRCWVA/
 --------- (15/15) NA  
  NS31446–1454 GDFDSVIDC/
 ---E----- (10/10)  
  NS5a1989–1997 SDFKTWLKA/
 ---R----- (11/11) 10  
CBO572 B*2302 E2445–456 HKFNSSGCPERL/
 NA NA resolved 
 DRB1*1001 NS31248–1257 GYKVLVNPSV/
 NA NA  

 
DRB5*0310
 
NS31380–1389
 
YGKAIPLEVI/
 NA
 
NA
 

 

Animal

Patr allele

HCV region

Wild-type sequence/
 escape mutations

Month of detection

Status
CBO603 A*0901 NS41963–1972 QWISSECTTPC/
 ----------- (8/24)
 ------S---- (2/24)
 --L-----A—- (1/24)
 --L-------- (13/24) 63a chronic 
CH-503 A*0401 E2588–596 KHPDATYSR/
 -------T- (9/9) 21 chronic 
 B*1601 E1233–241 GNASRCWVA/
 --------- (15/15) NA  
  NS31446–1454 GDFDSVIDC/
 ---E----- (10/10)  
  NS5a1989–1997 SDFKTWLKA/
 ---R----- (11/11) 10  
CBO572 B*2302 E2445–456 HKFNSSGCPERL/
 NA NA resolved 
 DRB1*1001 NS31248–1257 GYKVLVNPSV/
 NA NA  

 
DRB5*0310
 
NS31380–1389
 
YGKAIPLEVI/
 NA
 
NA
 

 
a

No sequencing performed between months 4 and 63 (reference 11).

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