Skip to Main Content
Table I.

Spleens Examined 48 h after the Indicated Dose of Listeria


L. monocytogenesdose

Mice

n

Pathology(48 h)

Apoptosis(48 h)
5 × 103 WT 30–50% - severe 3+ 
5 × 103 IFN-αβR−/− 10% - mild 1+ 
2.5 × 104 WT 50–100% - severe 4+ 
2.5 × 104 IFN-αβR−/− 10% - mild 1+ 
5 × 104 WT 75–100% - severe 4+ 
5 × 104
 
IFN-αβR−/−
 
6
 
20% - mild
 
1–2+
 

L. monocytogenesdose

Mice

n

Pathology(48 h)

Apoptosis(48 h)
5 × 103 WT 30–50% - severe 3+ 
5 × 103 IFN-αβR−/− 10% - mild 1+ 
2.5 × 104 WT 50–100% - severe 4+ 
2.5 × 104 IFN-αβR−/− 10% - mild 1+ 
5 × 104 WT 75–100% - severe 4+ 
5 × 104
 
IFN-αβR−/−
 
6
 
20% - mild
 
1–2+
 

In pathology, the percentage refers to the number of white pulp profiles showing the lesions. Severe means extensive depletion of lymphocytes, mostly in the periarteriolar lymphoid sheath but extending to peripheral areas of the pulp. Mild refers to a slight reduction localized to the periarteriolar lymphoid sheath. TUNEL analysis shows varying numbers of positive nuclei. Slides were scored blindly by one of us.

Close Modal

or Create an Account

Close Modal
Close Modal