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Table I.

Phenotypic Heterogeneity of Human CCR8+ T Cells from Skin and Blood


T cells

Subset

CLA

CD25

CD69

CD27

CD45RO

CD45RA

CCR4

CCR7

CXCR3
Skin CD4+ 65 ± 13a 37 ± 7 83 ± 9 59 ± 9 93 ± 8 37 ± 10 0b 8 ± 2 
 CD8+ 90 ± 1.5 63 ± 5 100 39 ± 14 100 65 ± 4 39 ± 4 
Blood CD25+ 100 100 100 100 100 40 

 
CD25
 
11 ± 4
 
0
 
0
 
100
 
45 ± 5
 
87 ± 3
 
0
 
64 ± 4
 
0
 

T cells

Subset

CLA

CD25

CD69

CD27

CD45RO

CD45RA

CCR4

CCR7

CXCR3
Skin CD4+ 65 ± 13a 37 ± 7 83 ± 9 59 ± 9 93 ± 8 37 ± 10 0b 8 ± 2 
 CD8+ 90 ± 1.5 63 ± 5 100 39 ± 14 100 65 ± 4 39 ± 4 
Blood CD25+ 100 100 100 100 100 40 

 
CD25
 
11 ± 4
 
0
 
0
 
100
 
45 ± 5
 
87 ± 3
 
0
 
64 ± 4
 
0
 
a

Mean ± SEM of three to nine independent experiments.

b

0 and 100 indicate <5 and >95% positive cells, respectively.

Freshly isolated CCR8+ T cells from skin and blood were analyzed for coexpression of various markers by flow cytometry.

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