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Table I.

Karyotypic Analysis of Pro-B and T Cell Lymphomas






Locus
 involvement


Amplification
Tumor
 no.
Genotype
Immunophenotype
Composite karyotype
TCR
IgH
Age of
 onset
IgH
c-myc
L796 Ku80−/−ATM+/+ Thymic lymphoma 39,X,-X, or Y, T(2:13)(B;C1),Rb(7.15),T(13;2)(B;B),+15 No n.d. 7 mo No No 
L2282 Ku80−/−ATM+/+ Thymic lymphoma 40,XX.T(3;14)(H4;E3) No n.d. 6 mo No No 
L2283 Ku80−/−ATM+/+ Thymic lymphoma 40,XX,T(7;14)(B;D),Rb(13.17),T(14;7)(C;C),+15 No n.d. 13 mo No No 
L387 Ku80−/−ATM+/− Thymic lymphoma 42,XY,del(12)(F),+Rb(14.14),-14[2],+15 No n.d. 7 mo No No 
L2240 Ku80−/−ATM+/− Thymic lymphoma 40,XX,Rb(5,18)[1],Rb(13.14)[1],Rb(15.15),+15 No n.d. 8 mo No No 
L3835 Ku80−/−ATM+/− Thymic lymphoma 42,X,T(X;4)(F;C),del(13)(A2→A5),+15,+T(15;1)(C;D) No n.d. 7 mo No No 
PKT1 Ku80−/−p53−/− Pro-B cell lymphoma 39–49,XY,+1,+5,T(12;15;3;[1]) OR T(12;15;3)x2,+14 n.d. Yes 2 mo Yes Yes 
PKT2 Ku80−/−p53−/− Pro-B cell lymphoma 39–41,XX,+3,T(12;15),dup(15) n.d. Yes 2 mo Yes Yes 
PKT3 Ku80−/−p53−/− Pro-B cell lymphoma 38–42,XY,T(12;15),T(15;12) OR T(15;12;16) n.d. Yes 2 mo Yes Yes 
PKT4 Ku80−/−p53−/− Pro-B cell lymphoma 39–40,XY,T(12;15),T(15;12),dup(16) n.d. Yes 2 mo Yes Yes 
PKT5–13 Ku80−/−p53−/− Pro-B cell lymphoma n.d. n.d. Yes 2 mo Yes Yes 
PK7T1 Ku70−/−p53−/− Pro-B cell lymphoma T(12;15),T(15;12;?) n.d. Yes 2 mo Yes Yes 
PK7T2 Ku70−/−p53−/− Pro-B cell lymphoma T(12;15) n.d. Yes 3 mo Yes Yes 
PK7T3 Ku70−/−p53−/− Pro-B cell lymphoma T(12;15),T(15;12;?) n.d. Yes 3 mo Yes Yes 
PK7T4 Ku70−/−p53−/− Pro-B cell lymphoma n.d. n.d. Yes 2 mo Yes Yes 
N10527 Ku80−/−p53−/−RAD54−/− Pro-B cell lymphoma T(12;15),T(15;12;3) n.d. Yes 1.5 mo Yes Yes 
N9984-B Ku80−/−p53−/−RAD54−/− Pro-B cell lymphoma T(12;15) n.d. Yes 3 mo No No 
N9984-T Ku80−/−p53−/−RAD54−/− Thymic lymphoma T(12;15),T(14;16),Rb(7.18) No n.d. 3 mo No No 
N10238 Ku80−/−p53+/−RAD54−/− Thymic lymphoma T(4;14),T(14;4),T(12;13) No n.d. 3 mo No No 
N10449 Ku80−/−p53+/−RAD54−/− Thymic lymphoma n.d. n.d. n.d. 4 mo No No 
N9454 Ku80−/−p53−/−RAG−/− Thymic lymphoma Polyploid, aneuploid No n.d. 3 mo No No 
N8839 Ku80−/−p53−/−RAG−/− Thymic lymphoma n.d. n.d. n.d. 3 mo No No 
N10611 Ku80−/−p53−/−RAG−/− Thymic lymphoma Polyploid, aneuploid No n.d. 3 mo No No 
N10184 Ku80−/−p53−/−RAG−/−a Thymic lymphoma Polyploid, aneuploid No n.d. 3 mo No No 
N9700 Ku80+/−p53−/−RAG−/−a Thymic lymphoma Polyploid, aneuploid No n.d. 4 mo No No 
N10214
 
Ku80+/−p53−/−RAG−/−a
 
Thymic lymphoma
 
Polyploid, aneuploid
 
No
 
n.d.
 
5 mo
 
No
 
No
 





Locus
 involvement


Amplification
Tumor
 no.
Genotype
Immunophenotype
Composite karyotype
TCR
IgH
Age of
 onset
IgH
c-myc
L796 Ku80−/−ATM+/+ Thymic lymphoma 39,X,-X, or Y, T(2:13)(B;C1),Rb(7.15),T(13;2)(B;B),+15 No n.d. 7 mo No No 
L2282 Ku80−/−ATM+/+ Thymic lymphoma 40,XX.T(3;14)(H4;E3) No n.d. 6 mo No No 
L2283 Ku80−/−ATM+/+ Thymic lymphoma 40,XX,T(7;14)(B;D),Rb(13.17),T(14;7)(C;C),+15 No n.d. 13 mo No No 
L387 Ku80−/−ATM+/− Thymic lymphoma 42,XY,del(12)(F),+Rb(14.14),-14[2],+15 No n.d. 7 mo No No 
L2240 Ku80−/−ATM+/− Thymic lymphoma 40,XX,Rb(5,18)[1],Rb(13.14)[1],Rb(15.15),+15 No n.d. 8 mo No No 
L3835 Ku80−/−ATM+/− Thymic lymphoma 42,X,T(X;4)(F;C),del(13)(A2→A5),+15,+T(15;1)(C;D) No n.d. 7 mo No No 
PKT1 Ku80−/−p53−/− Pro-B cell lymphoma 39–49,XY,+1,+5,T(12;15;3;[1]) OR T(12;15;3)x2,+14 n.d. Yes 2 mo Yes Yes 
PKT2 Ku80−/−p53−/− Pro-B cell lymphoma 39–41,XX,+3,T(12;15),dup(15) n.d. Yes 2 mo Yes Yes 
PKT3 Ku80−/−p53−/− Pro-B cell lymphoma 38–42,XY,T(12;15),T(15;12) OR T(15;12;16) n.d. Yes 2 mo Yes Yes 
PKT4 Ku80−/−p53−/− Pro-B cell lymphoma 39–40,XY,T(12;15),T(15;12),dup(16) n.d. Yes 2 mo Yes Yes 
PKT5–13 Ku80−/−p53−/− Pro-B cell lymphoma n.d. n.d. Yes 2 mo Yes Yes 
PK7T1 Ku70−/−p53−/− Pro-B cell lymphoma T(12;15),T(15;12;?) n.d. Yes 2 mo Yes Yes 
PK7T2 Ku70−/−p53−/− Pro-B cell lymphoma T(12;15) n.d. Yes 3 mo Yes Yes 
PK7T3 Ku70−/−p53−/− Pro-B cell lymphoma T(12;15),T(15;12;?) n.d. Yes 3 mo Yes Yes 
PK7T4 Ku70−/−p53−/− Pro-B cell lymphoma n.d. n.d. Yes 2 mo Yes Yes 
N10527 Ku80−/−p53−/−RAD54−/− Pro-B cell lymphoma T(12;15),T(15;12;3) n.d. Yes 1.5 mo Yes Yes 
N9984-B Ku80−/−p53−/−RAD54−/− Pro-B cell lymphoma T(12;15) n.d. Yes 3 mo No No 
N9984-T Ku80−/−p53−/−RAD54−/− Thymic lymphoma T(12;15),T(14;16),Rb(7.18) No n.d. 3 mo No No 
N10238 Ku80−/−p53+/−RAD54−/− Thymic lymphoma T(4;14),T(14;4),T(12;13) No n.d. 3 mo No No 
N10449 Ku80−/−p53+/−RAD54−/− Thymic lymphoma n.d. n.d. n.d. 4 mo No No 
N9454 Ku80−/−p53−/−RAG−/− Thymic lymphoma Polyploid, aneuploid No n.d. 3 mo No No 
N8839 Ku80−/−p53−/−RAG−/− Thymic lymphoma n.d. n.d. n.d. 3 mo No No 
N10611 Ku80−/−p53−/−RAG−/− Thymic lymphoma Polyploid, aneuploid No n.d. 3 mo No No 
N10184 Ku80−/−p53−/−RAG−/−a Thymic lymphoma Polyploid, aneuploid No n.d. 3 mo No No 
N9700 Ku80+/−p53−/−RAG−/−a Thymic lymphoma Polyploid, aneuploid No n.d. 4 mo No No 
N10214
 
Ku80+/−p53−/−RAG−/−a
 
Thymic lymphoma
 
Polyploid, aneuploid
 
No
 
n.d.
 
5 mo
 
No
 
No
 
a

Mice additionally expressing a rearranged T cell receptor transgene (AND). The AND transgene did not change the age of onset, the type of tumor or karyotype.

The immunophenotype as determined by FACS® analysis is indicated for each of the tumors. Due to the instability of some of the tumors, composite karyotypes represent the most commonly observed clonal aberrations by SKY. Due to the high chromosome instability and polyploid nature of the Ku/p53/RAG tumors, it was not possible to derive a representative composite karyotype. Ku70−/−p53−/− tumors were analyzed with painting probes specific for chromosomes 12 and 15. Columns labeled TCR and IgH refer to the involvement of these loci in chromosome translocations as determined by SKY and/or gene specific (Tcrα, Tcrβ, Ig VH, and Ig Cα) BAC probes. n.d., not determined.

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