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Table I.

Distribution of 14C-labeled CNI-1493 in Rat Tissues 60 min After Intravenous (1 mg/kg) and Intracerebroventricular (100 ng/kg) Injections


Tissue/organ

CNI-1493 after intravenous(1 mg/kg injection) g/mg tissue

CNI-1493 after i.c.v.(100 ng/kg) injection ng/mg tissue
Blood 4.5 ± 1.3 ND 
Brain 1.8 ± 0.3 1.6 ± 0.6 
Heart 3.3 ± 0.7 ND 
Intestine 12.6 ± 5.1 ND 
Kidney 18.6 ± 1.9 ND 
Liver 19.7 ± 5.4 ND 
Lung 13.0 ± 5.0 ND 
Muscle 2.7 ± 1.1 ND 
Skin 8.5 ± 2.5 ND 
Spleen
 
21.8 ± 2.1
 
ND
 

Tissue/organ

CNI-1493 after intravenous(1 mg/kg injection) g/mg tissue

CNI-1493 after i.c.v.(100 ng/kg) injection ng/mg tissue
Blood 4.5 ± 1.3 ND 
Brain 1.8 ± 0.3 1.6 ± 0.6 
Heart 3.3 ± 0.7 ND 
Intestine 12.6 ± 5.1 ND 
Kidney 18.6 ± 1.9 ND 
Liver 19.7 ± 5.4 ND 
Lung 13.0 ± 5.0 ND 
Muscle 2.7 ± 1.1 ND 
Skin 8.5 ± 2.5 ND 
Spleen
 
21.8 ± 2.1
 
ND
 
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