Primary CTL Activity and Function Are Normal in JNK1−/− and JNK2−/− Animals
. | . | Specific 51Cr releasea . | . | . | |
|---|---|---|---|---|---|
| Group . | Effector/
target ratio . | H-2b . | H-2d . | Clearance of
LCMV
from serab . | |
| JNK1−/− | 50:1 | 35 ± 4 | <1 | 4/4 | |
| 25:1 | 23 ± 3 | <1 | |||
| 12:1 | 14 ± 4 | <1 | |||
| JNK2−/− | 50:1 | 40 ± 6 | <1 | 4/4 | |
| 25:1 | 40 ± 2 | <1 | |||
| 12:1 | 22 ± 5 | <1 | |||
| JNK+/+ | 50:1 | 27 ± 4 | <1 | 4/4 | |
| 25:1 | 22 ± 3 | <1 | |||
| 12:1 | 14 ± 2 | <1 | |||
. | . | Specific 51Cr releasea . | . | . | |
|---|---|---|---|---|---|
| Group . | Effector/
target ratio . | H-2b . | H-2d . | Clearance of
LCMV
from serab . | |
| JNK1−/− | 50:1 | 35 ± 4 | <1 | 4/4 | |
| 25:1 | 23 ± 3 | <1 | |||
| 12:1 | 14 ± 4 | <1 | |||
| JNK2−/− | 50:1 | 40 ± 6 | <1 | 4/4 | |
| 25:1 | 40 ± 2 | <1 | |||
| 12:1 | 22 ± 5 | <1 | |||
| JNK+/+ | 50:1 | 27 ± 4 | <1 | 4/4 | |
| 25:1 | 22 ± 3 | <1 | |||
| 12:1 | 14 ± 2 | <1 | |||
Average of four mice per group, no statistical difference between groups.
To evaluate clearance of infectious virus, sera were harvested 8 d after LCMV inoculation while 2-3 d after inoculation with LCMV-ARM 2 × 105 PFU intraperitoneal viral titers range at 3 logs of infectious virus/ml of sera (references 23 and 34), at day 8 no detectable infectious virus was observed in any of the sera by plaque assay (reference 32).