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Table I.

Initial Demonstration of Colonization and Stimulation of Proinflammatory Cytokines and Chemokines after Intranasal Infection of Mice with Nontoxigenic V. cholerae




P4 (ctxAB::km)

Sham treated
Initial inoculum 2.3 × 107
 CFU in 20 μl 20 μl
 PBS buffer 
Mice surviving to 24 h 4/4 3/3 
CFU recovered from lung 2,300–23,300
 CFU/100 mg 
Health rating 1.9 ± 0.5a 5.0 ± 0.0 
Severity of pneumonia 13.5 ± 4.4a 2.0 ± 3.5 
TNFα (pg/100 mg lung) 1,000 ± 520
 (range 570–1,800)a <25 
IL-6 (pg/ml serum) 3,400 ± 2,700
 (range 830–6,600)a <37 
MIP-2 (pg/ml serum)
 
2,100 ± 2,600
 (range 230–5,032)a
 
<120
 



P4 (ctxAB::km)

Sham treated
Initial inoculum 2.3 × 107
 CFU in 20 μl 20 μl
 PBS buffer 
Mice surviving to 24 h 4/4 3/3 
CFU recovered from lung 2,300–23,300
 CFU/100 mg 
Health rating 1.9 ± 0.5a 5.0 ± 0.0 
Severity of pneumonia 13.5 ± 4.4a 2.0 ± 3.5 
TNFα (pg/100 mg lung) 1,000 ± 520
 (range 570–1,800)a <25 
IL-6 (pg/ml serum) 3,400 ± 2,700
 (range 830–6,600)a <37 
MIP-2 (pg/ml serum)
 
2,100 ± 2,600
 (range 230–5,032)a
 
<120
 
a

Significantly different from sham-treated mice at P < 0.05.

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