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Table 1

Lymphocyte Populations in mkk7−/− Chimeric Mice

Subsetsmkk7+/− →rag1−/mkk7−/− →rag1−/
Thymus   
Total cell number (×1079.84 ± 2.2 22.5 ± 4.6 
CD4+CD8+ (%) 81.2 ± 7.6 88.9 ± 2.3 
CD4+CD8+ (%) 11.8 ± 5.0 7.60 ± 1.2 
CD4+CD8+ (%) 2.5 ± 0.8 1.2 ± 0.4 
Spleen   
Total cell number (×1072.90 ± 0.6 2.74 ± 0.4 
TCRα/β+ (%) 36.3 ± 4.3 33.8 ± 4.9 
B220+sIgM+ (%) 29.9 ± 5.4 27.8 ± 5.6 
Lymph node   
Total cell number (×1072.96 ± 0.4 3.14 ± 0.3 
CD4+CD8 (%) 53.2 ± 4.0 43.6 ± 2.6 
CD4CD8+ (%) 19.7 ± 1.6 15.5 ± 2.8 
Subsetsmkk7+/− →rag1−/mkk7−/− →rag1−/
Thymus   
Total cell number (×1079.84 ± 2.2 22.5 ± 4.6 
CD4+CD8+ (%) 81.2 ± 7.6 88.9 ± 2.3 
CD4+CD8+ (%) 11.8 ± 5.0 7.60 ± 1.2 
CD4+CD8+ (%) 2.5 ± 0.8 1.2 ± 0.4 
Spleen   
Total cell number (×1072.90 ± 0.6 2.74 ± 0.4 
TCRα/β+ (%) 36.3 ± 4.3 33.8 ± 4.9 
B220+sIgM+ (%) 29.9 ± 5.4 27.8 ± 5.6 
Lymph node   
Total cell number (×1072.96 ± 0.4 3.14 ± 0.3 
CD4+CD8 (%) 53.2 ± 4.0 43.6 ± 2.6 
CD4CD8+ (%) 19.7 ± 1.6 15.5 ± 2.8 

7–12-wk-old mkk7+/−→rag1−/− and mkk7−/−→rag1−/− mice were used. Total cells from thymi (n = 8), spleen (n = 5), and lymph nodes (n = 5) were stained with Abs against the indicated proteins and populations determined by FACScan™. Bold numbers indicate statistically significant differences between mkk7+/− and mkk7−/− chimeric mice (Student's t test; P < 0.05). Values are given as the mean ± S.E.M.

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