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Table III.

Mutation frequency in GL 5′ Sμ segments from splenic B cells induced for 4 d with LPS + α-δ-dex


polβ+/+
polβ−/−


Mutation frequency ×10−4(number)
p-valuea
Total mutations 16 (31) 33.1 (75) <0.001 
Mutations at A:T 6.7 (13) 18.1 (41) 0.001 
Mutations at G:C 9.3 (18) 15 (34) 0.126 
Mutations at AID hotspotb 4.1 (8) 9.7 (22) 0.042 
nt's analyzed 19,388 22,634  

polβ+/+
polβ−/−


Mutation frequency ×10−4(number)
p-valuea
Total mutations 16 (31) 33.1 (75) <0.001 
Mutations at A:T 6.7 (13) 18.1 (41) 0.001 
Mutations at G:C 9.3 (18) 15 (34) 0.126 
Mutations at AID hotspotb 4.1 (8) 9.7 (22) 0.042 
nt's analyzed 19,388 22,634  
a

Significance of difference between WT and polβ/ mutations (Fisher's exact test).

b

Mutations within the underlined C or G in the WRC/GYW hotspot motifs.

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