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Table II.

Mutation frequency in recombined Sμ–Sγ3 segments from splenic B cells induced for 4 d with LPS + α-δ-dex


polβ+/+
polβ−/−


Mutation frequency ×10−4 (number)
p-valuea
Sμ    
    Total mutations 29.6 (60) 51.2 (88) 0.001 
    Mutations at A:T 10.4 (21) 23.3 (40) 0.003 
    Mutations at G:C 19.2 (39) 27.9 (48) 0.085 
    Mutations at AID hotspotb 15.8 (32) 18.6 (32) 0.533 
    nt's analyzed 20,274 17,202  
Sγ3    
    Total mutations 19.8 (70) 25.1 (94) 0.138 
    Mutations at A:T 6.8 (24) 11.2 (42) 0.05 
    Mutations at G:C 13 (46) 13.9 (52) 0.762 
    Mutations at AID hotspotb 8.8 (31) 8.3 (31) 0.899 
    nt's analyzed 35,364 37,437  

polβ+/+
polβ−/−


Mutation frequency ×10−4 (number)
p-valuea
Sμ    
    Total mutations 29.6 (60) 51.2 (88) 0.001 
    Mutations at A:T 10.4 (21) 23.3 (40) 0.003 
    Mutations at G:C 19.2 (39) 27.9 (48) 0.085 
    Mutations at AID hotspotb 15.8 (32) 18.6 (32) 0.533 
    nt's analyzed 20,274 17,202  
Sγ3    
    Total mutations 19.8 (70) 25.1 (94) 0.138 
    Mutations at A:T 6.8 (24) 11.2 (42) 0.05 
    Mutations at G:C 13 (46) 13.9 (52) 0.762 
    Mutations at AID hotspotb 8.8 (31) 8.3 (31) 0.899 
    nt's analyzed 35,364 37,437  
a

Significance of difference between WT and polβ/ mutations (Fisher's exact test).

b

Mutations within the underlined C or G in the WRC/GYW hotspot motifs.

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