Skip to Main Content
Table I.

Blunt DSBs in Sμa from pol β/ and WT littermate splenic B cells occur preferentially at the G:C bp and at WRC/GYW hotspots

nt at DSB
polβ+/+
polβ−/−
Sequenceb
A:T 20%c 6.5% 43.3% 
C:G 80% 93.5% 56.7% 
Hotspots 50% 41.9% 23.2% 
Totald 30 breaks 31 breaks 2,000 nt's 
nt at DSB
polβ+/+
polβ−/−
Sequenceb
A:T 20%c 6.5% 43.3% 
C:G 80% 93.5% 56.7% 
Hotspots 50% 41.9% 23.2% 
Totald 30 breaks 31 breaks 2,000 nt's 
a

Sites of DSBs determined with both the 5′ Sμ and 3′ Sμ primers are combined.

b

Frequency at which the nt or motif occurs in the Sμ sequence analyzed.

c

Percentage of DSBs located at the indicated bp or at the underlined C or G in the WRC/GYW motif.

d

Total number of DSBs analyzed.

Close Modal

or Create an Account

Close Modal
Close Modal