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Table I.

Total bacterial translocation to distant organs after hemorrhagic shocka


Groups

High fat

Fasted

 
CFU/g tissue
 
CFU/g tissue
 
Sham-VGX 16 (0–65) 412 (206–517) 
VGX 328 (183–1459) 542 (164–849) 
Sham-VGX + CCK-ra 267 (158–837)b  
Sham-VGX + vehicle (CCK-ra) 57 (23–217)  
Sham-VGX + chlorisondamine 226 (34–1410)b 172 (56–488) 
Sham-VGX + vehicle (Chlor.)
 
22 (5–71)
 

 

Groups

High fat

Fasted

 
CFU/g tissue
 
CFU/g tissue
 
Sham-VGX 16 (0–65) 412 (206–517) 
VGX 328 (183–1459) 542 (164–849) 
Sham-VGX + CCK-ra 267 (158–837)b  
Sham-VGX + vehicle (CCK-ra) 57 (23–217)  
Sham-VGX + chlorisondamine 226 (34–1410)b 172 (56–488) 
Sham-VGX + vehicle (Chlor.)
 
22 (5–71)
 

 
a

P < 0.05 compared with VGX.

b

P < 0.05 compared with vehicle treated.

All rats were subjected to hemorrhagic shock. Mesenteric lymph nodes, spleen, and liver were cultured at sacrifice (90 min). High fat–treated or fasted rats were subjected to (sham) vagotomy (VGX) and treated with CCK-receptor antagonists (CCK-ra), chlorisondamine, or vehicle where indicated. Total bacterial translocation is expressed as CFU/g tissue. Results are median (range); n = 6/group.

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