Skip to Main Content
Table 1

Comparison of Different Parameters in Young, Middle-aged, and Old Rats

ParameterYoungMiddle-agedOldSignificance level
Weight (g) 305 ± 8* 537 ± 7* 514 ± 20* *P < 0.0001 for Y vs. M and Y vs. O 
Systolic RR (mmHg) 121 ± 4 117 ± 4 117 ± 2 NS 
Heart rate (bpm) 334 ± 13 323 ± 14 344 ± 13 NS 
Maximal relaxations (%)     
Ach −96 ± 2* −89 ± 2* −62 ± 3* *P < 0.0001 for Y vs. O and M vs. O 
A23187 −76 ± 1* −74 ± 4* −47 ± 4* *P < 0.0001 for Y vs. O and M vs. O 
SNP  −111 ± 2 −107 ± 1 −105 ± 1 NS 
Maximal NO release (nmol/liter) 690 ± 50* 490 ± 70* 200 ± 30* *P < 0.0001 for Y vs. O 
     *P < 0.001 for M vs. O 
    *P < 0.01 for M vs. Y 
NOS activity (pmol/min/mg)     
Total 120 ± 13* − 216 ± 26* *P < 0.01 
eNOS 23 ± 10** − 144 ± 14** **P < 0.001 
iNOS 97 ± 15 − 72 ± 12 NS 
Superoxide (cpm/mg dry wt)     
Basal 2,302 ± 323* 2,145 ± 220* 6,058 ± 445* *P < 0.0001 for Y vs. O and M vs. O 
Stimulated 82,495 ± 6,033** 108,439 ± 2,612 175,058 ± 36,080** **P < 0.01 
ParameterYoungMiddle-agedOldSignificance level
Weight (g) 305 ± 8* 537 ± 7* 514 ± 20* *P < 0.0001 for Y vs. M and Y vs. O 
Systolic RR (mmHg) 121 ± 4 117 ± 4 117 ± 2 NS 
Heart rate (bpm) 334 ± 13 323 ± 14 344 ± 13 NS 
Maximal relaxations (%)     
Ach −96 ± 2* −89 ± 2* −62 ± 3* *P < 0.0001 for Y vs. O and M vs. O 
A23187 −76 ± 1* −74 ± 4* −47 ± 4* *P < 0.0001 for Y vs. O and M vs. O 
SNP  −111 ± 2 −107 ± 1 −105 ± 1 NS 
Maximal NO release (nmol/liter) 690 ± 50* 490 ± 70* 200 ± 30* *P < 0.0001 for Y vs. O 
     *P < 0.001 for M vs. O 
    *P < 0.01 for M vs. Y 
NOS activity (pmol/min/mg)     
Total 120 ± 13* − 216 ± 26* *P < 0.01 
eNOS 23 ± 10** − 144 ± 14** **P < 0.001 
iNOS 97 ± 15 − 72 ± 12 NS 
Superoxide (cpm/mg dry wt)     
Basal 2,302 ± 323* 2,145 ± 220* 6,058 ± 445* *P < 0.0001 for Y vs. O and M vs. O 
Stimulated 82,495 ± 6,033** 108,439 ± 2,612 175,058 ± 36,080** **P < 0.01 

Y, young; M, middle-aged; O, old; RR, blood pressure; bpm, beats per minute.

Close Modal

or Create an Account

Close Modal
Close Modal