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Table II

Effect of CCR5 inactivation on induction of immunoregulatory factors in the brain by WNV


DAI

Infection

Strain

IL-1β

IL-4

IL-10

IFN-α

IFN-γ

TNF-α

ICAM-1

MMP-9

TIMP-1
mock CCR5+/+ 0.04 ± 0.02 BLD BLD BLD BLD BLD 14.6 ± 0.5 4.8 ± 0.6 0.4 ± 0.03 
mock CCR5−/− 0.2 ± 0.02 BLD BLD BLD 0.07 ± 0.01 BLD 10.6 ± 0.3 4.1 ± 0.4 0.4 ± 0.04 
WNV CCR5+/+ 0.3 ± 0.01 BLD BLD 9.0 ± 2.0 0.08 ± 0.05 0.7 ± 0.3 47.5 ± 7.6 53.9 ± 10.1 11.8 ± 3.0 
WNV CCR5−/− 0.2 ± 0.07 BLD BLD 6.0 ± 2.1 0.14 ± 0.08 0.3 ± 0.2 41.1 ± 7.3 28.9 ± 7.6 10.9 ± 3.2 
12 WNV CCR5+/+ 0.3 ± 0.08 BLD BLD 0.2 ± 0.1 0.09 ± 0.07 BLD 41.2 ± 3.7 25.1 ± 12.8 9.1 ± 1.7 
12
 
WNV
 
CCR5−/−
 
0.2 ± 0.07
 
BLD
 
BLD
 
0.1 ± 0.07
 
0.06 ± 0.05
 
BLD
 
29.5 ± 8.5
 
12.5 ± 4.2
 
1.3 ± 0.01a
 

DAI

Infection

Strain

IL-1β

IL-4

IL-10

IFN-α

IFN-γ

TNF-α

ICAM-1

MMP-9

TIMP-1
mock CCR5+/+ 0.04 ± 0.02 BLD BLD BLD BLD BLD 14.6 ± 0.5 4.8 ± 0.6 0.4 ± 0.03 
mock CCR5−/− 0.2 ± 0.02 BLD BLD BLD 0.07 ± 0.01 BLD 10.6 ± 0.3 4.1 ± 0.4 0.4 ± 0.04 
WNV CCR5+/+ 0.3 ± 0.01 BLD BLD 9.0 ± 2.0 0.08 ± 0.05 0.7 ± 0.3 47.5 ± 7.6 53.9 ± 10.1 11.8 ± 3.0 
WNV CCR5−/− 0.2 ± 0.07 BLD BLD 6.0 ± 2.1 0.14 ± 0.08 0.3 ± 0.2 41.1 ± 7.3 28.9 ± 7.6 10.9 ± 3.2 
12 WNV CCR5+/+ 0.3 ± 0.08 BLD BLD 0.2 ± 0.1 0.09 ± 0.07 BLD 41.2 ± 3.7 25.1 ± 12.8 9.1 ± 1.7 
12
 
WNV
 
CCR5−/−
 
0.2 ± 0.07
 
BLD
 
BLD
 
0.1 ± 0.07
 
0.06 ± 0.05
 
BLD
 
29.5 ± 8.5
 
12.5 ± 4.2
 
1.3 ± 0.01a
 
a

P < 0.02 when compared to CCR5+/+ mice at the same day after infection.

BLD; below the level of detection; DAI, days after infection.

Data are pooled from two to three individual experiments with two to three mice in each group and are presented as the mean ± SEM. Units are expressed as nanograms per gram of brain tissue.

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