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Table 2

Frequency of CD95 Mutations in Human B Cell Subsets; Single-Cell Analysis from Donors II–VII

Mutations per cellMutation frequency
B cell subset; phenotype5′ regionExon IX5′ regionExon IX
   × 10−4/bp 
Naive; IgD+IgM+CD27 1/48 0/66 0.3 <0.2 
GC; CD38+CD77+ 12/60 2/45 2.5 0.7 
anti-CD95–resistant GC; annexin V–negative, CD38+ 4/10 12/22 5.0 7.7 
Memory; IgDCD20+CD27+ 6/17 0/33 3.1 <0.4 
Mutations per cellMutation frequency
B cell subset; phenotype5′ regionExon IX5′ regionExon IX
   × 10−4/bp 
Naive; IgD+IgM+CD27 1/48 0/66 0.3 <0.2 
GC; CD38+CD77+ 12/60 2/45 2.5 0.7 
anti-CD95–resistant GC; annexin V–negative, CD38+ 4/10 12/22 5.0 7.7 
Memory; IgDCD20+CD27+ 6/17 0/33 3.1 <0.4 
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