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Table 1

Proposed Homeostatic Roles of Mouse CD1 and Other Nonpolymorphic MHC-like Molecules

MHC or MHC-like moleculeFunctional binding grooveCargoRecognition by lymphocyte receptorInteracting ligand and/or cell typesProposed homeostatic function
Classical      
Class I Peptide CD8/TCR-α/β T cells Host defense 
Class II Peptide CD4/TCR-α/β T cells Host defense 
Nonpolymorphic      
CD1 Lipid CD4+ or DN NK, CD8α/α+, γ/δ T cells Lipid membrane integrity? 
H2-M3 Formylated peptide CD4/TCR-α/β T cells Mitochondrial integrity? 
HLA-E (Qa-1) MHC I leader peptide CD94/NKG2A, B, C NK cells, and CD8+ T cells Class I MHC expression 
HLA-G Peptide ILT-2, p49 KIR NK and T cells Materno-fetal tolerance 
MIC-A/MIC-B − Unknown CD94/NKG2D NK, γ/δ T cells, CD8+ T cells Gut epithelial integrity? 
FcRn − IgG IgG Serum Ig 
ZAG Probable Lipid Unknown Unknown Lipid metabolism? 
HFE − TfR Transferrin/iron/TfR Iron 
MHC or MHC-like moleculeFunctional binding grooveCargoRecognition by lymphocyte receptorInteracting ligand and/or cell typesProposed homeostatic function
Classical      
Class I Peptide CD8/TCR-α/β T cells Host defense 
Class II Peptide CD4/TCR-α/β T cells Host defense 
Nonpolymorphic      
CD1 Lipid CD4+ or DN NK, CD8α/α+, γ/δ T cells Lipid membrane integrity? 
H2-M3 Formylated peptide CD4/TCR-α/β T cells Mitochondrial integrity? 
HLA-E (Qa-1) MHC I leader peptide CD94/NKG2A, B, C NK cells, and CD8+ T cells Class I MHC expression 
HLA-G Peptide ILT-2, p49 KIR NK and T cells Materno-fetal tolerance 
MIC-A/MIC-B − Unknown CD94/NKG2D NK, γ/δ T cells, CD8+ T cells Gut epithelial integrity? 
FcRn − IgG IgG Serum Ig 
ZAG Probable Lipid Unknown Unknown Lipid metabolism? 
HFE − TfR Transferrin/iron/TfR Iron 
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