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Table 4

Frequency and Affinity of AFCs at Day 42 of the Primary Response

Anti-NP IgG1 AFCs per 105 Input Cells at Day 42
SpleenBone marrow
NP2NP13RatioNP2NP13RatioP value
Control 1.3 ± 1.1 1.4 ± 0.9 0.9 ± 0.04 7.9 ± 6.6 10.2 ± 9.3 0.8 ± 0.03 0.46 
bcl-2 18.0 ± 9.0 64.8 ± 33.0 0.3 ± 0.01 21.3 ± 12 31.0 ± 17.0 0.7 ± 0.01 <0.001 
P value   <0.001   0.43  
Anti-NP IgG1 AFCs per 105 Input Cells at Day 42
SpleenBone marrow
NP2NP13RatioNP2NP13RatioP value
Control 1.3 ± 1.1 1.4 ± 0.9 0.9 ± 0.04 7.9 ± 6.6 10.2 ± 9.3 0.8 ± 0.03 0.46 
bcl-2 18.0 ± 9.0 64.8 ± 33.0 0.3 ± 0.01 21.3 ± 12 31.0 ± 17.0 0.7 ± 0.01 <0.001 
P value   <0.001   0.43  
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