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Table 3

Sequence Analysis of Clonal Ig and TCR-β Gene Rearrangements

CaseGene locusRearrangementPotentially functionalPercent mutationRemarks
IgH VH2-5–DH3-10–JH5b No 4.3 Stop (codon 91) 
  DH3-9–JH6c n.a. 0.9  
     TCR-β loci in germline 
II IgH VH1-8–DH3-22–JH6b No 3.5 47-bp deletion; 
 IgH VH3-53–DH2-2–JH6b No 1.9 Stop in CDR3 
 Igκ Vκ1 (L12)–Jκ1 No 1.3 Stop in CDR3 
     TCR-β loci in germline 
III TCR-β Vβ7.1–Dβ1–Jβ1.6 Yes 0.3–0.7 Sequence variations involving codons 98, 105, and 108; three variants 
 TCR-β Dβ1–Jβ1.4 n.a.  
     IgH locus in germline 
CaseGene locusRearrangementPotentially functionalPercent mutationRemarks
IgH VH2-5–DH3-10–JH5b No 4.3 Stop (codon 91) 
  DH3-9–JH6c n.a. 0.9  
     TCR-β loci in germline 
II IgH VH1-8–DH3-22–JH6b No 3.5 47-bp deletion; 
 IgH VH3-53–DH2-2–JH6b No 1.9 Stop in CDR3 
 Igκ Vκ1 (L12)–Jκ1 No 1.3 Stop in CDR3 
     TCR-β loci in germline 
III TCR-β Vβ7.1–Dβ1–Jβ1.6 Yes 0.3–0.7 Sequence variations involving codons 98, 105, and 108; three variants 
 TCR-β Dβ1–Jβ1.4 n.a.  
     IgH locus in germline 

n.a., not applicable.

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