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Table 1

Case Description of Patients with cHD

CaseIIIIII
Age 31 26 51 
Sex Male Male Male 
Presentation First First First 
LN biopsy site Abdominal Cervical Inguinal 
Stage IIB II 
Hodgkin subtype Mixed cellularity Mixed cellularity Nodular sclerosis 
Phenotype of H/RS cells    
CD30 
CD15 
CD20 − − − 
CD3 − − − 
TCR-α/β − ND − 
Granzyme B + (90%) + (60%) + (40%) 
Perforin − − + (100%) 
TIA-1 + (60%) + (>90%) + (40%) 
EBV − 
ALK − ND − 
CaseIIIIII
Age 31 26 51 
Sex Male Male Male 
Presentation First First First 
LN biopsy site Abdominal Cervical Inguinal 
Stage IIB II 
Hodgkin subtype Mixed cellularity Mixed cellularity Nodular sclerosis 
Phenotype of H/RS cells    
CD30 
CD15 
CD20 − − − 
CD3 − − − 
TCR-α/β − ND − 
Granzyme B + (90%) + (60%) + (40%) 
Perforin − − + (100%) 
TIA-1 + (60%) + (>90%) + (40%) 
EBV − 
ALK − ND − 

Numbers in parentheses indicate percentages of positive Reed-Sternberg cells. Presence or absence of EBV was determined by amplification of a fragment of the EBNA1 gene from single H/RS cells, and the results were further confirmed in case I by LMP1 staining and in case III by EBER in situ hybridization. ALK expression is indicative for the t(2;5) translocation resulting in the expression of a fusion molecule with NPM.

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