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Table I

Clinical Parameters in (PLSJL/J)F1 Mice Immunized with Microbial Mimicry Peptides and Challenged for EAE Induction with gpSCH

IFA immunization*EAE challengePercentage of incidenceMean day of disease onsetMean peak disease severity
IFA alone  gpSCH  100    9 ± 1  
MBPp85–99 (ENPVVHFFKNIVTPR)  gpSCH   95  16 ± 2  3.6 ± 0.9 
HPV 7 (IGGRVHFFKDISPIA)§  gpSCH   60  17 ± 2  2.3 ± 1.2 
HPV 13 (IGGRVHFFKDISPIS)  gpSCH   60  16 ± 3  2.3 ± 0.4 
HPV 40 (IGGRVHFFRDISPIG)  gpSCH   20  21  1 
Bacillus subtilis ORF (RKVVTDFFKNIPQRI)  gpSCH    0   0  0 
HPV 32 (IGSRVHFFHDISPIT)  gpSCH   20  13  3 
IFA immunization*EAE challengePercentage of incidenceMean day of disease onsetMean peak disease severity
IFA alone  gpSCH  100    9 ± 1  
MBPp85–99 (ENPVVHFFKNIVTPR)  gpSCH   95  16 ± 2  3.6 ± 0.9 
HPV 7 (IGGRVHFFKDISPIA)§  gpSCH   60  17 ± 2  2.3 ± 1.2 
HPV 13 (IGGRVHFFKDISPIS)  gpSCH   60  16 ± 3  2.3 ± 0.4 
HPV 40 (IGGRVHFFRDISPIG)  gpSCH   20  21  1 
Bacillus subtilis ORF (RKVVTDFFKNIPQRI)  gpSCH    0   0  0 
HPV 32 (IGSRVHFFHDISPIT)  gpSCH   20  13  3 
*

 Groups of 20 animals were used for data analysis.  

P < 0.01 by Student's t test compared with immunization with IFA alone.  

§

 Amino acid homologies with the peptide MBPp87–99 are in bold.  

 Note that the HPV 7 sequence we use is three amino acids shorter at its NH2 terminus than that used by Ufret-Vincenty et al. (1).  

P < 0.001 by Student's t test compared with immunization with MBPp87–99.  

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