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Table I

Effect of Aminoguanidine Treatment in X-CGD Mice

Wk after infectionAGParasite burdenPercentage of infected foci showing granuloma formation
    LDU   
2  −  3,065 ± 173  37 ± 5 
   5,214 ± 251*   9 ± 2* 
 −           810 ± 146  88 ± 10 
   2,550 ± 128*   93 ± 8 
Wk after infectionAGParasite burdenPercentage of infected foci showing granuloma formation
    LDU   
2  −  3,065 ± 173  37 ± 5 
   5,214 ± 251*   9 ± 2* 
 −           810 ± 146  88 ± 10 
   2,550 ± 128*   93 ± 8 

Starting 1 d after L. donovani infection, X-CGD mice received acidified drinking water alone or the same water containing AG at 1% (wt/vol) for 4 wk. Results indicate mean ± SEM values from two experiments, and for liver parasite burdens represent eight mice per group and for granuloma formation (percentage of liver-infected foci showing developing or mature granulomas; see Table II) represent six mice per group.  

*

 Significantly different (P < 0.05) from control mice.  

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