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Table 2

Cytokine-mediated Cellular Activation in Latently Infected, Resting CD4+ T Cells

Cytokine added% CD4+/HLA-DR+% CD4+/CD25+
Day 0  No cytokine   0.7   0.0 
Day 6  No cytokine   1.0   1.2 
  IL-1β   0.8   0.9 
  IL-2   5.7   3.3 
  IL-4   3.2   5.0 
  IL-6   1.5   1.0 
  TNF-α   0.5   0.4 
  IL-2/IL-6/TNF-α  23.7   8.3 
  anti-CD3-stimulated  50.6  92.2 
Cytokine added% CD4+/HLA-DR+% CD4+/CD25+
Day 0  No cytokine   0.7   0.0 
Day 6  No cytokine   1.0   1.2 
  IL-1β   0.8   0.9 
  IL-2   5.7   3.3 
  IL-4   3.2   5.0 
  IL-6   1.5   1.0 
  TNF-α   0.5   0.4 
  IL-2/IL-6/TNF-α  23.7   8.3 
  anti-CD3-stimulated  50.6  92.2 

Purified, resting CD4+ T cells from one HIV-1–seronegative and two HIV-1–infected individuals were incubated with the indicated single cytokine, combination of cytokines, or with anti-CD3 antibody for 6 d and the expression of CD25 and HLA-DR was determined by FACS. Percentage of CD4/CD25- and CD4/HLA-DR-positive cells are indicated. A representative set of results from patient no. 2 is shown.  

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