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Table 1

Tumorigenicity of C26/IL-12 and Induction of both Memory Response and CMC to Parental C26 Cells in BALB/c and GKO Mice

RecipientsNo. of cells injectedPrimary responseSecondary response*CMC on targets (% lysis of target)
C26F1
BALB/c  5 × 104  10/17§  6/6§  E/T       
  5 × 105        0/17            1/9    50  40.7  12.6 
          25  36.9   7.5 
          12  22.4   5.1 
GKO  5 × 104        8/17            0/7  E/T       
  5 × 105       11/16            0/2    50  76.3  15.3 
          25  58.8  10.1 
          12  40.3   6.3 
RecipientsNo. of cells injectedPrimary responseSecondary response*CMC on targets (% lysis of target)
C26F1
BALB/c  5 × 104  10/17§  6/6§  E/T       
  5 × 105        0/17            1/9    50  40.7  12.6 
          25  36.9   7.5 
          12  22.4   5.1 
GKO  5 × 104        8/17            0/7  E/T       
  5 × 105       11/16            0/2    50  76.3  15.3 
          25  58.8  10.1 
          12  40.3   6.3 
*

 Mice that were tumor-free at day 60 were challenged subcutaneously with 105 C26 cells.  

 Tumor-free mice, which were not challenged, were killed and their splenocytes were tested for CMC activity in vitro. Splenocytes were restimulated in vitro with irradiated C26 cells for 5 d before CMC assay.  

§

 No. of mice with tumor/no. of mice injected.  

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