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Table 3

Kidney Pathology and Relative Levels of Antinuclear Antibodies in Female IFN-γ Transgenic Mice

AnimalAnti- dsDNAAntihistoneKidney pathology
10  0.143  0.019  Mild mesangial GN 
11  0.186  0.194  Mild mesangial GN 
12  0.148  0.070  Severe diffuse proliferative GN 
13  0.160  0.653  Mild mesangial GN 
14  0.303  0.101  Severe diffuse proliferative GN 
15  0.173  1.094  Mild mesangial GN 
16  0.510  0.063  Severe diffuse proliferative GN 
AnimalAnti- dsDNAAntihistoneKidney pathology
10  0.143  0.019  Mild mesangial GN 
11  0.186  0.194  Mild mesangial GN 
12  0.148  0.070  Severe diffuse proliferative GN 
13  0.160  0.653  Mild mesangial GN 
14  0.303  0.101  Severe diffuse proliferative GN 
15  0.173  1.094  Mild mesangial GN 
16  0.510  0.063  Severe diffuse proliferative GN 

Antibody levels are expressed as OD measured at 492 nm. Anti-dsDNA and antihistone ELISAs were carried out at dilutions of 1:250 and 1:1,000, respectively.  

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