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Table 1

Recognition of CD8+ Influenza Epitopes by Freshly Isolated T Cells in the ELISPOT Assay for IFN-γ and Corresponding Peptide-specific T Cell Frequencies

ProteinSequenceMHC class I restrictionNo. of respondersNo. of donors testedRange of peptide-specific IFNγ SFCs (effector frequencies)/PBMC
M1 58–66  GILGFVFTL  HLA-A2.01    1/111,000–1/3,500 
NP 380–388  ELRSRYWAI  HLA-B8    1/67,000–1/15,000 
NP 265–273  ILRGSVAHK  HLA-A3    1/83,000–1/45,000 
PB1 591–599  VSDGGPNLY  HLA-A1    1/100,000–1/91,000 
MI 128–135  ASCMGLIY  HLA-B35    1/25,000–1/16,000 
NP 383–391  SRYWAIRTR  HLA-B27.05    1/24,000 
ProteinSequenceMHC class I restrictionNo. of respondersNo. of donors testedRange of peptide-specific IFNγ SFCs (effector frequencies)/PBMC
M1 58–66  GILGFVFTL  HLA-A2.01    1/111,000–1/3,500 
NP 380–388  ELRSRYWAI  HLA-B8    1/67,000–1/15,000 
NP 265–273  ILRGSVAHK  HLA-A3    1/83,000–1/45,000 
PB1 591–599  VSDGGPNLY  HLA-A1    1/100,000–1/91,000 
MI 128–135  ASCMGLIY  HLA-B35    1/25,000–1/16,000 
NP 383–391  SRYWAIRTR  HLA-B27.05    1/24,000 
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