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Table 8

Effect of iNOS Inhibitor in IL-12–treated GKO Mice

Treatment started after week 2Liver parasite burden (LDU)
Weeks after infection
23
None (control)  2,251 ± 578  4,665 ± 611 
IL-12    −  1,539 ± 338* 
IL-12 plus AG    −  4,545 ± 717 
Treatment started after week 2Liver parasite burden (LDU)
Weeks after infection
23
None (control)  2,251 ± 578  4,665 ± 611 
IL-12    −  1,539 ± 338* 
IL-12 plus AG    −  4,545 ± 717 

Starting 2 wk after infection, GKO mice were treated with IL-12 (1 μg/day) for 7 d with or without the addition of 1% AG to the drinking water. Results are mean LDU ± SEM values from two experiments with 6–10 mice per timepoint.  

*

 Significantly different (P <0.05) from control mice at week 3.  

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