Effect of Aminoguanidine on L. donovani–infected Normal Mice
| Strain . | . | AG Treatment . | . | Liver parasite burden (LDU) . | ||
|---|---|---|---|---|---|---|
| . | Week after infection . | |||||
| . | 2 . | . | 4 . | |||
| BALB/c | − | 1,748 ± 125 (6) | 569 ± 127 (9) | |||
| + | 1,746 ± 74 (6) | 2,450 ± 255 (9)* | ||||
| GKO +/+ | − | 2,854 ± 214 (3) | 978 ± 213 (6) | |||
| + | 2,166 ± 81 (3) | 2,919 ± 194 (6)* | ||||
| Strain . | . | AG Treatment . | . | Liver parasite burden (LDU) . | ||
|---|---|---|---|---|---|---|
| . | Week after infection . | |||||
| . | 2 . | . | 4 . | |||
| BALB/c | − | 1,748 ± 125 (6) | 569 ± 127 (9) | |||
| + | 1,746 ± 74 (6) | 2,450 ± 255 (9)* | ||||
| GKO +/+ | − | 2,854 ± 214 (3) | 978 ± 213 (6) | |||
| + | 2,166 ± 81 (3) | 2,919 ± 194 (6)* | ||||
12 h after L. donovani challenge, treatment with 1% AG was begun and given continuously for 4 wk. Results are mean ± SEM values for (n) mice from two experiments in BALB/c mice and one experiment in GKO +/+ mice.
Significantly different from 4-wk untreated control value (P <0.05)