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Table 7

Effect of Aminoguanidine on L. donovani–infected Normal Mice

StrainAG TreatmentLiver parasite burden (LDU)
Week after infection
24
BALB/c  −  1,748 ± 125 (6)      569 ± 127 (9) 
   1,746 ± 74 (6)  2,450 ± 255 (9)* 
       
GKO +/+  −  2,854 ± 214 (3)      978 ± 213 (6) 
   2,166 ± 81 (3)  2,919 ± 194 (6)* 
StrainAG TreatmentLiver parasite burden (LDU)
Week after infection
24
BALB/c  −  1,748 ± 125 (6)      569 ± 127 (9) 
   1,746 ± 74 (6)  2,450 ± 255 (9)* 
       
GKO +/+  −  2,854 ± 214 (3)      978 ± 213 (6) 
   2,166 ± 81 (3)  2,919 ± 194 (6)* 

12 h after L. donovani challenge, treatment with 1% AG was begun and given continuously for 4 wk. Results are mean ± SEM values for (n) mice from two experiments in BALB/c mice and one experiment in GKO +/+ mice.  

*

 Significantly different from 4-wk untreated control value (P <0.05)  

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