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Table 6

iNOS mRNA Expression in Livers of GKO Mice

Time after infection and treatmentiNOS Detected
No. samples (%)
Uninfected       0/3 (0) 
2 Weeks  1/6 (17) 
3 Weeks      0/6 (0) 
3 Weeks plus IL-12  4/6 (67) 
3 Weeks plus IL-12 plus anti-TNF      0/6 (0) 
3 Weeks plus IL-12 plus control serum  4/5 (80) 
4 Weeks  4/8 (50) 
Time after infection and treatmentiNOS Detected
No. samples (%)
Uninfected       0/3 (0) 
2 Weeks  1/6 (17) 
3 Weeks      0/6 (0) 
3 Weeks plus IL-12  4/6 (67) 
3 Weeks plus IL-12 plus anti-TNF      0/6 (0) 
3 Weeks plus IL-12 plus control serum  4/5 (80) 
4 Weeks  4/8 (50) 

Liver RNA was assayed for the expression of iNOS message by qualitative RT-PCR. Where indicated, IL-12 treatment (1 μg/d for 7 d) was begun at the end of week 2 with or without simultaneous twiceweekly injections of anti–TNF-α or normal rabbit serum. Results are from 2–3 experiments at each timepoint.  

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