Skip to Main Content
Table 5

Effect of IL-12 on Visceral Infection in GKO Mice

TreatmentLiver parasite burdens (LDU)
Week 2Week 3
None (control)  2,556 ± 468 (9)  5,343 ± 777 (8) 
IL-12    1,687 ± 300 (8)* 
IL-12 plus anti–TNF-α    8,514 ± 782 (8) 
IL-12 plus control antiserum    2,725 ± 288 (9) 
Saline plus control antiserum    6,428 ± 826 (5) 
TreatmentLiver parasite burdens (LDU)
Week 2Week 3
None (control)  2,556 ± 468 (9)  5,343 ± 777 (8) 
IL-12    1,687 ± 300 (8)* 
IL-12 plus anti–TNF-α    8,514 ± 782 (8) 
IL-12 plus control antiserum    2,725 ± 288 (9) 
Saline plus control antiserum    6,428 ± 826 (5) 

2 wk after infection, GKO mice were treated by pump for 7 d with IL-12 (1 μg/d) or saline. Where indicated, mice were also injected during the week of IL-12 treatment with either anti–TNF-a antiserum or control serum given every 3 d starting just after pump insertion. Results are from three experiments, and represent mean ± SEM values for (n) mice.  

*

 Significantly different (P <0.05) from control mice at week 2 and week 3.  

 Significantly different (P <0.05) from control mice at week 3.  

Close Modal

or Create an Account

Close Modal
Close Modal