Effect of Anti–TNF-α on Visceral Infection in GKO Mice
| Treatment during weeks 8–12 . | . | Liver Parasite Burden (LDU) . | ||
|---|---|---|---|---|
| Week 8 . | . | Week 12 . | ||
| None (control) | 9,788 ± 579 | 4,187 ± 636 | ||
| Normal serum | 3,943 ± 469 | |||
| Anti–TNF-α | 10,202 ± 1,361 | |||
| Treatment during weeks 8–12 . | . | Liver Parasite Burden (LDU) . | ||
|---|---|---|---|---|
| Week 8 . | . | Week 12 . | ||
| None (control) | 9,788 ± 579 | 4,187 ± 636 | ||
| Normal serum | 3,943 ± 469 | |||
| Anti–TNF-α | 10,202 ± 1,361 | |||
Starting 8 wk after infection, GKO mice were injected twice-weekly with either normal rabbit serum or anti–TNF-α antiserum. Results are mean LDU ± SEM from two experiments with 5–6 mice per group. P <0.002 for anti–TNF-α–treated group versus untreated and normal saline-treated mice.