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Table 1

Liver Histologic Response to L. donovani Infection

Hepatic infection and cellular responseWeeks after infection
Normal BALB/cGKO
2481224812
Liver burden (LDU)  1,547  537  143  212  3,264  7,648  9,113  4,821 
Infected foci  128  147  52  70  123  248  265  172 
No cellular reaction (%)  29     80  46  24  22 
KC fusion alone (%)  27  11    12  35  52  39 
KD fusion plus infiltrate (%)  27  33  14    12  17  21 
Granulomas (%)  16  56  85  98     18 
Hepatic infection and cellular responseWeeks after infection
Normal BALB/cGKO
2481224812
Liver burden (LDU)  1,547  537  143  212  3,264  7,648  9,113  4,821 
Infected foci  128  147  52  70  123  248  265  172 
No cellular reaction (%)  29     80  46  24  22 
KC fusion alone (%)  27  11    12  35  52  39 
KD fusion plus infiltrate (%)  27  33  14    12  17  21 
Granulomas (%)  16  56  85  98     18 

Liver histologic sections of normal BALB/c and GKO mice were examined for amastigote burdens (LDU) and tissue cellular reactions. 25 × 40 fields were counted and scored as no cellular reaction including no Kupffer cell fusion (KC); fused KC alone; fusion with a developing cellular infiltrate (early granuloma formation); or fully formed granuloma (11). Results indicate mean values for four mice at each timepoint (eccept BALB/c, week 12; n = 3 mice). SEM was <14%.  

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