Skip to Main Content
Table 3

Protection of SCID Mice from Amebic Liver Abscess by Transfer of Rabbit Antisera Raised against Recombinantly Expressed Fragments of the 170-kD Lectin

Vaccine groupNo. of SCID mice with liver abscess/No. of SCID mice challengedPercent protectedPercent liver abscessed in nonprotected mice
      mean ± SD 
Preimmune  19/19 (4/4, 5/5, 5/5, 5/5)   0.0  17.1 ± 7.8 
Anti-r170CP  8/8 (5/5, 3/3)   0.0  28.2 ± 12.6* 
Anti-r170PR  5/8 (3/5, 2/3)  37.5   3.2 ± 1.2* 
Anti-r170CR2a  8/8 (5/5, 3/3)   0.0   7.6 ± 3.8* 
Anti-r170CR2a  2/5 (2/5)  60.0   5.5 
Anti-r170CR2b  2/5 (2/5)  60.0   9.3 
Anti-r170CR2c  3/5 (3/5)  40.0   8.3 
Anti-r170CR2a + b + c  7/15 (2/5, 2/5, 3/5)   53.3   7.7 ± 1.8* 
Vaccine groupNo. of SCID mice with liver abscess/No. of SCID mice challengedPercent protectedPercent liver abscessed in nonprotected mice
      mean ± SD 
Preimmune  19/19 (4/4, 5/5, 5/5, 5/5)   0.0  17.1 ± 7.8 
Anti-r170CP  8/8 (5/5, 3/3)   0.0  28.2 ± 12.6* 
Anti-r170PR  5/8 (3/5, 2/3)  37.5   3.2 ± 1.2* 
Anti-r170CR2a  8/8 (5/5, 3/3)   0.0   7.6 ± 3.8* 
Anti-r170CR2a  2/5 (2/5)  60.0   5.5 
Anti-r170CR2b  2/5 (2/5)  60.0   9.3 
Anti-r170CR2c  3/5 (3/5)  40.0   8.3 
Anti-r170CR2a + b + c  7/15 (2/5, 2/5, 3/5)   53.3   7.7 ± 1.8* 
*

 Significant difference from preimmune control (P <0.05), as determined by Fisher's exact test.  

 5× concentrated anti-r170CR2a antiserum with low antibody titer to peptide 5.  

Close Modal

or Create an Account

Close Modal
Close Modal